Microcalorimetry in the Screening of Discovery Compounds and in the Investigation of Novel Drug-Delivery systems

Beezer, Anthony E. and Mitchell, John C. and Colegate, Rachel M. and Scally, David J. and Twyman, Lance J. and Willson, Richard J. (1995) Microcalorimetry in the Screening of Discovery Compounds and in the Investigation of Novel Drug-Delivery systems. In: 9th Conference of the International-Society-for-Biological-Calorimetry, Berlin-Schmerwitz, Germany. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/0040-6031(94)01966-K

Abstract

Calorimetry has for some time been proposed as a rapid method for determination of bioactivity. This paper describes the background to this application and describes how it has been extended to the study of bioassay techniques via microcalorimetry in the development of structure activity relationships (sARs). That sARs can be developed indicates that it is possible to guide drug synthetic strategy through the results of microcalorimetric investigations, and this approach is explored here. In an extension of this approach it is argued that microcalorimetry is well suited to the examination of novel drug delivery systems, allowing investigation of the capacity of drug delivery molecules to release the drug in the presence of a target organism.

Item Type: Conference or workshop item (Other)
Uncontrolled keywords: BIOASSAY; DENDRIMER; DRUG DELIVERY; MICROCALORIMETRY
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Computing > Theoretical Computing Group
Depositing User: P. Ogbuji
Date Deposited: 08 Jun 2009 11:19
Last Modified: 06 May 2014 09:11
Resource URI: http://kar.kent.ac.uk/id/eprint/19699 (The current URI for this page, for reference purposes)
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