Osses, N. and Sobrevia, L. and Cordova, C. and Jarvis, S.M. and Yudilevich, D.L. (1995) Transport and metabolism of adenosine in diabetic human placenta. Reproduction Fertility and Development, 7 (6). pp. 1499-1503. ISSN 1031-3613 .
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Pregnancy complicated by diabetes is a relatively frequent event and may result in fetal embriopathy. However, little is known regarding whether placental transport functions are altered. In this study, we have compared the activity of the nitrobenzyithioinosine (NBMPR)-sensitive adenosine transporter and adenosine metabolism in human placental brush-border- and basal-membrane vesicles from placentas of normal and diabetic pregnancies. Neither [H-3]NBMPR binding, a marker of the facilitative-diffusion nucleoside transporter in the human placenta, nor adenosine metabolism exhibited a significant difference in either the brush-border- or the basal-membrane vesicles between the normal and diabetic group, except for an increased affinity in [H-3]NBMPR binding at the basal side in diabetic placenta. This result contrasts with an earlier finding using the same group of patients that adenosine transport is downregulated in umbilical vein endothelial cells from diabetic pregnancies. It is concluded that adenosine transport is modulated selectively in different tissues in diabetic pregnancies.
|Additional information:||Document Type: Proceedings Paper. Conference Information: 1st International Meeting of World Placenta Associations UNIV NEWCASTLE, SYDNEY, AUSTRALIA, OCT 24-28, 1994|
|Subjects:||Q Science > QL Zoology
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||O.O. Odanye|
|Date Deposited:||02 Jun 2009 09:49|
|Last Modified:||17 Jul 2012 11:01|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/19429 (The current URI for this page, for reference purposes)|
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