Getting the glycosylation right: Implications for the biotechnology industry

Jenkins, N. and Parekh, R.B. and James, D.C. (1996) Getting the glycosylation right: Implications for the biotechnology industry. Nature Biotechnology, 14 (8). pp. 975-981. ISSN 1087-0156. (The full text of this publication is not available from this repository)

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Abstract

Glycosylation is the most extensive of all the posttranslational modifications, and has important functions in the secretion, antigenicity and clearance of glycoproteins. In recent years major advances have been made in the cloning of glycosyltransferase enzymes, in understanding the varied biological functions of carbohydrates, and in the accurate analysis of glycoprotein heterogeneity. In this review we discuss the impact of these advances on the choice of a recombinant host cell line, in optimizing cell culture processes, and in choosing the appropriate level of glycosylation analysis for each stage of product development.

Item Type: Review
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: R.F. Xu
Date Deposited: 04 Jun 2009 16:09
Last Modified: 04 Jun 2009 16:09
Resource URI: http://kar.kent.ac.uk/id/eprint/19265 (The current URI for this page, for reference purposes)
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