Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Pickup, David M. and Moss, Rob M. and Qui, D. and Newport, Robert J. and Valappil, Sabeel P. and Knowles, Jonathan C. and Smith, Mark E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 (6). 064708. ISSN 0021-9606. (Full text available)

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http://dx.doi.org/10.1063/1.3076057

Abstract

Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron

Item Type: Article
Additional information: Grant Number from STFC EP/C000714 EP/C000633 GR/T21080
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group
Depositing User: J.M. Smith
Date Deposited: 18 May 2009 12:58
Last Modified: 23 Jun 2014 13:10
Resource URI: http://kar.kent.ac.uk/id/eprint/19150 (The current URI for this page, for reference purposes)
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