Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Pickup, Dave M and Moss, Robert M and Qui, D. and Newport, Robert J. and Valappil, S.P. and Knowles, Jonathan C. and Smith, M (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 (6). 064708. ISSN 0021-9606. (Full text available)

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http://dx.doi.org/10.1063/1.3076057

Abstract

Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron

Item Type: Article
Additional information: Grant Number from STFC EP/C000714 EP/C000633 GR/T21080
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group
Depositing User: J.M. Smith
Date Deposited: 18 May 2009 12:58
Last Modified: 08 Apr 2014 07:45
Resource URI: http://kar.kent.ac.uk/id/eprint/19150 (The current URI for this page, for reference purposes)
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