Structure and properties of strontium-doped phosphate-based glasses

Abou Neel, Ensanya A. and Chrzanowski, Wojciech and Pickup, David M. and O'Dell, Luke A. and Morden, Nicola J. and Newport, Robert J. and Smith, Mark E. and Knowles, Jonathan C. (2009) Structure and properties of strontium-doped phosphate-based glasses. Journal of the Royal Society, Interface, 6 (34). pp. 435-446. ISSN 1742-5689 . (Full text available)

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http://dx.doi.org/10.1098/rsif.2008.0348

Abstract

Owing to similarity in both ionic size and polarity, strontium (Sr2+) is known to behave in a comparable way to calcium (Ca2+), and its role in bone metabolism has been well documented as both anti-resorptive and bone forming. In this study, novel quaternary strontium-doped phosphate-based glasses, containing 1, 3 and 5 mol% SrO, were synthesized and characterized. P-31 magic angle spinning (MAS) nuclear magnetic resonance results showed that, as the Sr2+ content is increased in the glasses, there is a slight increase in disproportionation of Q(2) phosphorus environments into Q(1) and Q(3) environments. Moreover, shortening and strengthening of the phosphorus to bridging oxygen distance occurred as obtained from FTIR. The general broadening of the spectral features with Sr2+ content is most probably due to the increased variation of the phosphate cation bonding interactions caused by the introduction of the third cation. This increased disorder may be the cause of the increased degradation of the Sr-containing glasses relative to the Sr-free glass. As confirmed from elemental analysis, all Sr-containing glasses showed higher Na2O than expected and this also could be accounted for by the higher degradation of these glasses compared with Sr-free glasses. Measurements of surface free energy (SFE) showed that incorporation of strontium had no effect on SFE, and samples had relatively higher fractional polarity, which is not expected to promote high cell activity. From viability studies, however, the incorporation of Sr2+ showed better cellular response than Sr2+-free glasses, but still lower than the positive control. This unfavourable cellular response could be due to the high degradation nature of these glasses and not due to the presence of Sr2+.

Item Type: Article
Additional information: EPSRC Grant Numbers EP/C004671/1 EP/C004698/1 EP/C515560/1
Uncontrolled keywords: phosphate-based glasses; biocompatibility; surface free energy; ion release; FTIR spectroscopy; nuclear magnetic resonance
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group
Depositing User: J.M. Smith
Date Deposited: 18 May 2009 11:12
Last Modified: 19 Jun 2014 11:35
Resource URI: http://kar.kent.ac.uk/id/eprint/19147 (The current URI for this page, for reference purposes)
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