Costs Of Antifungal Prophylaxis After Bone-Marrow Transplantation - A Model Comparing Oral Fluconazole, Liposomal Amphotericin And Oral Polyenes As Prophylaxis Against Oropharyngeal Infections

Stewart, Alan and Powles, Ray and Hewetson, Margaret and Antrum, Judy and Richardson, Celia and Mehta, Jayesh (1995) Costs Of Antifungal Prophylaxis After Bone-Marrow Transplantation - A Model Comparing Oral Fluconazole, Liposomal Amphotericin And Oral Polyenes As Prophylaxis Against Oropharyngeal Infections. Pharmacoeconomics, 8 (4). pp. 350-361. ISSN 1170-7690. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.2165/00019053-199508040-00009

Abstract

We used a costs model to compare alternative modes of prophylaxis against oropharyngeal fungal infections in patients with leukaemia or myeloma who had undergone bone marrow transplantation (BMT). We compared 2 innovative pharmaceutical options (oral fluconazole and intravenous liposomal amphotericin) with existing standard practice (oral polyenes). Costs were measured over a 12-week treatment period, and were compared with the 2 effectiveness measures: (i) the avoidance of colonisation or infection; and (ii) the patients' ability to continue with prophylaxis in an uninfected state. The costs and effectiveness of BMT itself were not considered in this evaluation. The costs per successfully treated patient over a 12-week period were pound 28 956 (pound 1 = $US1.60, June 1995) for oral fluconazole, pound 53 225 for liposomal amphotericin and pound 32 768 for oral polyenes. Sensitivity analysis showed that the costs of liposomal amphotericin always exceeded those of the oral comparators, reflecting its high acquisition, preparation and administration costs.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Personal Social Services Research Unit
Depositing User: I.T. Ekpo
Date Deposited: 29 Jun 2011 09:32
Last Modified: 08 Apr 2014 13:48
Resource URI: http://kar.kent.ac.uk/id/eprint/19077 (The current URI for this page, for reference purposes)
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