Blower, P.J. and Lewis, J.S. and Zweit, J. (1996) Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nuclear Medicine and Biology, 23 (8). pp. 957-980. ISSN 0883-2897.
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| Official URL http://dx.doi.org/10.1016/S0969-8051(96)00130-8 |
Abstract
The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed. Copper radionuclides offer application in positron emission tomography, targeted radiotherapy, and single photon imaging. The chemistry of copper is relatively simple and well-suited to radiopharmaceutical application. Current radiopharmaceuticals include biomolecules labelled via bifunctional chelators primarily based on cyclic polyaminocarboxylates and polyamines, and pyruvaldehyde-bis(N-4-methylthiosemicarbazone) (PTSM) and its analogues. The chemistry of copper, of which only a fraction has yet been exploited, is likely to be applied more fully in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | copper; radiopharmaceuticals; imaging; targeted radiotherapy; PET; PTSM |
| Subjects: | R Medicine |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | M.A. Ziai |
| Date Deposited: | 16 May 2009 11:49 |
| Last Modified: | 16 May 2009 11:49 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/18823 (The current URI for this page, for reference purposes) |
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