Macindoe, W.M. and Williams, A. and Khan, R. (1996) Tin(IV)-functionalised polymer supports; Non-toxic and practical reagents for regioselective acetylation of sucrose. Carbohydrate Research, 283 . pp. 17-25. ISSN 0008-6215.
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Polymer-supported butyltin(IV) reagents have been surveyed for regioselectivity in acetylation of sucrose. Polymer-supported butyltin(IV) dichloride 8 catalysed the acetylation of sucrose to give a 59% yield of 6-O-acetyl sucrose 3, the precursor of sucralose. The yield is close to that of a previously reported process involving dibutyltin(IV) oxide (Bu(2)SnO). The spent polymeric resin could readily be regenerated and can be subsequently used in further synthetic reactions.
|Uncontrolled keywords:||sucralose; butyltin(IV) dichloride, polymer-supported; acetylation, regioselective; 6-O-acetyl sucrose; regenerated polymer|
|Subjects:||Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QD Chemistry
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
|Divisions:||Faculties > Science Technology and Medical Studies > School of Physical Sciences|
|Depositing User:||F.D. Zabet|
|Date Deposited:||26 Jun 2009 10:52|
|Last Modified:||26 Jun 2009 10:52|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/18657 (The current URI for this page, for reference purposes)|
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