Tin(IV)-functionalised polymer supports; Non-toxic and practical reagents for regioselective acetylation of sucrose

Macindoe, Wallace M. and Williams, Andrew and Khan, Riaz (1996) Tin(IV)-functionalised polymer supports; Non-toxic and practical reagents for regioselective acetylation of sucrose. Carbohydrate Research, 283 . pp. 17-25. ISSN 0008-6215. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/0008-6215(95)00392-4

Abstract

Polymer-supported butyltin(IV) reagents have been surveyed for regioselectivity in acetylation of sucrose. Polymer-supported butyltin(IV) dichloride 8 catalysed the acetylation of sucrose to give a 59% yield of 6-O-acetyl sucrose 3, the precursor of sucralose. The yield is close to that of a previously reported process involving dibutyltin(IV) oxide (Bu(2)SnO). The spent polymeric resin could readily be regenerated and can be subsequently used in further synthetic reactions.

Item Type: Article
Uncontrolled keywords: sucralose; butyltin(IV) dichloride, polymer-supported; acetylation, regioselective; 6-O-acetyl sucrose; regenerated polymer
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QD Chemistry
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: F.D. Zabet
Date Deposited: 26 Jun 2009 10:52
Last Modified: 25 Jun 2014 13:21
Resource URI: http://kar.kent.ac.uk/id/eprint/18657 (The current URI for this page, for reference purposes)
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