Kallinteri, P. and Higgins, S. and Hutcheon, G.A. and St Pourcain, C.B. and Garnett, M.C. (2005) Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules, 6 (4). pp. 1885-1894. ISSN 1525-7797.
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We have prepared and screened a library of novel functionalized polymers for development of nanoparticle drug delivery systems. The polymer backbone consisting of two ester-linked, nontoxic, biological monomers, Glycerol and adipic acid, was prepared using a hydrolytic enzyme. The specificity of the chosen enzyme yields a linear polymer with one free pendant hydroxyl group per repeat unit, which can be further functionalized. This protocol gives control over the backbone polymer molecular weight, together with the ability to incorporate various amounts of different fatty acyl substituents. These functionalized polymers are able to self-assemble into well-defined small particles of high homogeneity with a very low toxicity. They are able to incorporate a water soluble drug, dexamethasone phosphate, with a high efficiency and drug loading which varies with the polymer specification. The above characteristics strongly suggest that these polymers could be developed into useful nanoparticulate drug delivery systems.
|Additional information:||945JI Times Cited:22 Cited References Count:37|
|Uncontrolled keywords:||in-vitro loaded nanoparticles plga nanoparticles nanospheres water polyesters polymerization derivatives liposomes devices|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Paraskevi Kallinteri|
|Date Deposited:||31 May 2009 08:01|
|Last Modified:||31 May 2009 08:01|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/18616 (The current URI for this page, for reference purposes)|
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