Novel functionalized biodegradable polymers for nanoparticle drug delivery systems

Kallinteri, Paraskevi and Higgins, Sean and Hutcheon, Gillian A. and St Pourcain, Christopher B. and Garnett, Martin C. (2005) Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules, 6 (4). pp. 1885-1894. ISSN 1525-7797. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1021/bm049200j

Abstract

We have prepared and screened a library of novel functionalized polymers for development of nanoparticle drug delivery systems. The polymer backbone consisting of two ester-linked, nontoxic, biological monomers, Glycerol and adipic acid, was prepared using a hydrolytic enzyme. The specificity of the chosen enzyme yields a linear polymer with one free pendant hydroxyl group per repeat unit, which can be further functionalized. This protocol gives control over the backbone polymer molecular weight, together with the ability to incorporate various amounts of different fatty acyl substituents. These functionalized polymers are able to self-assemble into well-defined small particles of high homogeneity with a very low toxicity. They are able to incorporate a water soluble drug, dexamethasone phosphate, with a high efficiency and drug loading which varies with the polymer specification. The above characteristics strongly suggest that these polymers could be developed into useful nanoparticulate drug delivery systems.

Item Type: Article
Additional information: 945JI Times Cited:22 Cited References Count:37
Uncontrolled keywords: in-vitro loaded nanoparticles plga nanoparticles nanospheres water polyesters polymerization derivatives liposomes devices
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Paraskevi Kallinteri
Date Deposited: 31 May 2009 08:01
Last Modified: 25 Apr 2014 14:12
Resource URI: http://kar.kent.ac.uk/id/eprint/18616 (The current URI for this page, for reference purposes)
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