Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization

Kallinteri, Paraskevi and Antimisiaris, Sophia G. (2001) Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization. International Journal of Pharmaceutics, 221 (1-2). pp. 219-226. ISSN 0378-5173. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/S0378-5173(01)00688-3

Abstract

The solubility of seven drugs (nitrofurantoin, chlorothiazide, phenobarbital, prednisolone, griseofulvin, diazepam and piroxicam) in the absence and presence of gelatin was measured, at three different pH values (3.7, 5.0 and 7.0) at 37 degreesC. Drugs studied had different physicochemical properties (log P, pK(a), aqueous solubility) and their solubility in presence of 0.1 and 0.5%, (w/v) hydrolyzed land in some cases common) gelatin was estimated. Results show that the solubility of all drugs is significantly enhanced, especially in the presence of 0.5%;, gelatin. This gelatin-induced enhancement in drug solubility is higher in the pH in which acidic drugs are less ionized, especially for the less lipophilic acidic drugs (nitrofurantoin, chlorothiazide). In all cases, drug solubility in presence of gelatin is correlated with their aqueous solubility. Therefore, the established relationships between aqueous and gelatin solubility can be employed to derive an estimate of the drug solubility in presence of gelatin once its aqueous solubility is known. With the exception of piroxicam which is highly ionized and phenobarbital which is relatively soluble, there seems to be a tendency for larger gelatin-induced increases in solubility as drug lipophilicity increases or aqueous solubility decreases.

Item Type: Article
Additional information: 443XJ Times Cited:12 Cited References Count:14
Uncontrolled keywords: solubility gelatin hydrolyzed gelatin drugs water-soluble gelatin anionic compounds delivery dissolution binding digoxin system milk
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Paraskevi Kallinteri
Date Deposited: 27 May 2009 15:15
Last Modified: 08 Apr 2014 08:28
Resource URI: http://kar.kent.ac.uk/id/eprint/18610 (The current URI for this page, for reference purposes)
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