Tuite, M.F. and Lindquist, S.L (2007) Maintenance and inheritance of yeast prions. PRION , 1 (2). 101 -109 . ISSN 1933-6896 .
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The unusual genetic behaviour of two yeast extrachromosomal elements [PSI] and [URE3] is entirely consistent with a prion-like mechanism of inheritance involving an autocatalytic alteration in the conformation of a normal cellular protein. In the case of both yeast determinants the identity of the underlying cellular prion protein is known. The discovery that the molecular chaperone Hsp104 is essential for the establishment and maintenance of the [PSI] determinant provides an explanation for several aspects of the puzzling genetic behaviour of these determinants. What remains to be explained is whether these determinants represent 'disease states' of yeast or represent the first examples of a unique mechanism for producing a heritable change in phenotype without an underlying change in genotype.
|Uncontrolled keywords:||yeast; [PSI]; prion; SUP35/eRF3; SUP45/eRF1; antisuppressor; [PSI+] maintenance genes; Hsp104; prion antagonists|
|Subjects:||Q Science > QP Physiology (Living systems) > QP517 Biochemistry|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||P. Ogbuji|
|Date Deposited:||02 May 2009 16:58|
|Last Modified:||02 May 2009 16:58|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/18550 (The current URI for this page, for reference purposes)|
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