Montanari, C.A. and Tute, M.S. (1997) A neural network analysis for antileishmaniasis compounds. Quantitative Structure-Activity Relationships, 16 (6). pp. 480-481. ISSN 0931-8771.
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Pentamidine analogues bind to the minor groove by using the pharmacophoric conformation as being isohelical do DNA. A QSAR model has disclosed three physiochemical descriptors as being important for such compounds against Leishmania mexicana amazonensis: Clog P, electrotopological index and Carbo similarity index. A comparison of the QSAR equation derived from multiple regression analysis, MRA, and the one from neural network analysis, NN, shows the latter to be of higher significance.
|Uncontrolled keywords:||neural network; multiple regression analysis; DNA minor groove binders; pentamidine analogues; antileishmaniasis compounds|
|Subjects:||R Medicine > R Medicine (General)
Q Science > QD Chemistry
|Divisions:||Faculties > Science Technology and Medical Studies > School of Physical Sciences|
|Depositing User:||M.A. Ziai|
|Date Deposited:||22 Sep 2009 12:07|
|Last Modified:||22 Sep 2009 12:07|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/18197 (The current URI for this page, for reference purposes)|
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