Eukaryotic initiation factor 2B (eIF2B)

Webb, B.L.J. and Proud, C.G. (1997) Eukaryotic initiation factor 2B (eIF2B). International Journal of Biochemistry & Cell Biology, 29 (10). pp. 1127-1131. ISSN 1357-2725. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/S1357-2725(97)00039-3

Abstract

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses. It may be regulated directly by its own phosphorylation, phosphorylation of its substrate, eIF2 and by allosteric effecters. Understanding its regulation will lead to a better knowledge of insulin action, regulation of the immune system and of insulin production in the pancreas. (C) 1997 Elsevier Science Ltd.

Item Type: Article
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: T.J. Sango
Date Deposited: 29 Apr 2009 15:36
Last Modified: 29 Apr 2009 15:36
Resource URI: http://kar.kent.ac.uk/id/eprint/18026 (The current URI for this page, for reference purposes)
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