Parenteral thiamine and Wernicke's encephalopathy: The balance of risks and perception of concern

Thomson, Allan D. and Cook, Chrostopher C. H. (1997) Parenteral thiamine and Wernicke's encephalopathy: The balance of risks and perception of concern. Alcohol and Alcoholism, 32 (3). pp. 207-209. ISSN 0735-0414. (The full text of this publication is not available from this repository)

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http://alcalc.oxfordjournals.org/content/32/3/207....

Abstract

Wernicke's encephalopathy, a disorder with significant mortality and high morbidity, is common amongst alcohol-dependent patients. Thiamine deficiency appears to play a key role in its aetiology, and parenteral high-dose thiamine is effective in prophylaxis and treatment. Unfortunately, reports of rare anaphylactoid reactions have led to a dramatic reduction in the use of parenteral thiamine, and it is possible that this change in treatment has led, or will lead, to an increase in morbidity and mortality. There is a need for education of doctors who treat alcohol-dependent patients, in order to ensure appropriate use of parenteral thiamine in prophylaxis and treatment of this disorder.

Item Type: Article
Subjects: R Medicine
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: T.J. Sango
Date Deposited: 05 May 2009 10:06
Last Modified: 22 Apr 2014 09:35
Resource URI: http://kar.kent.ac.uk/id/eprint/17999 (The current URI for this page, for reference purposes)
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