Sluss, H.K. and Han, Z.Q. and Barrett, T. and Goberdhan, D.C.I. and Wilson, C. and Davis, R.J. and Ip, Y.T. (1997) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila (vol 10, pg 2745, 1996). Genes & Development, 11 (4). p. 541. ISSN 0890-9369.
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The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and join at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.
|Subjects:||Q Science > QR Microbiology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||T.J. Sango|
|Date Deposited:||12 May 2009 11:06|
|Last Modified:||12 May 2009 11:06|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17957 (The current URI for this page, for reference purposes)|
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