Novel biotransformations to produce aromatic and heterocyclic aldehydes

Simmonds, J. and Robinson, Gary K. (1997) Novel biotransformations to produce aromatic and heterocyclic aldehydes. Enzyme and Microbial Technology, 21 (5). pp. 367-374. ISSN 0141-0229. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/S0141-0229(97)86532-5

Abstract

Aromatic aldehydes may be produced by Pseudomonas putida ATCC 12633 via biotransformation of benzoylformate and substrate analogues using the mandelic acid pathway. A reduction in pH to 5.4 causes the partial inactivation of the benzaldehyde dehydrogenase isoenzymes within this pathway, thereby allowing the accumulation of the aldehyde. The reduction in dehydrogenase activity with pH is a general phenomenon affecting all dehydrogenases within the cell and is not restricted to the benzaldehyde dehydrogenases of the mandelate pathway. Both benzaldehyde and thiophene-2-carboxaldehyde have been produced with yields of over 85%. (C) 1997 Elsevier Science Inc.

Item Type: Article
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: T.J. Sango
Date Deposited: 13 May 2009 06:08
Last Modified: 05 Jun 2014 10:26
Resource URI: http://kar.kent.ac.uk/id/eprint/17951 (The current URI for this page, for reference purposes)
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