Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*)

Hohmann, Claudia and Schneider, Kathrin and Bruntner, Christina and Irran, Elisabeth and Nicholson, Graeme and Bull, Alan T. and Jones, Amanda L. and Brown, Roselyn and Stach, James E.M. and Goodfellow, Michael and Beil, Winfried and Kramer, Marco and Imhoff, Johannes F. and Sussmuth, Roderich D. and Fiedler, Hans-Peter (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*). Journal Antibiot (Tokyo), 62 (2). pp. 99-104. ISSN 0021-8820 . (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1038/ja.2008.24

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.The Journal of Antibiotics (2009) 62, 99-104; doi:10.1038/ja.2008.24; published online 23 January 2009.

Item Type: Article
Uncontrolled keywords: benzoxazole antibiotic, fermentation, isolation, marine Streptomyces, structural elucidation
Subjects: Q Science
R Medicine > RS Pharmacy and materia medica
Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 12 Aug 2009 09:17
Last Modified: 01 May 2014 15:07
Resource URI: http://kar.kent.ac.uk/id/eprint/17850 (The current URI for this page, for reference purposes)
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