Hohmann, C. and Schneider, K. and Bruntner, C. and Irran, E. and Nicholson, G. and Bull, A.T. and Jones, A.L. and Brown, R. and Stach, J.E. and Goodfellow, M. and Beil, W. and Kramer, M. and Imhoff, J.F. and Sussmuth, R.D. and Fiedler, H.P. (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*). Journal Antibiot (Tokyo), 62 (2). pp. 99-104. ISSN 0021-8820 .
| The full text of this publication is not available from this repository. (Contact us about this Publication) | |
| Official URL http://dx.doi.org/10.1038/ja.2008.24 |
Abstract
Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.The Journal of Antibiotics (2009) 62, 99-104; doi:10.1038/ja.2008.24; published online 23 January 2009.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | benzoxazole antibiotic, fermentation, isolation, marine Streptomyces, structural elucidation |
| Subjects: | Q Science R Medicine > RS Pharmacy and materia medica Q Science > QR Microbiology |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group |
| Depositing User: | Sue Davies |
| Date Deposited: | 12 Aug 2009 09:17 |
| Last Modified: | 12 Aug 2009 09:17 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/17850 (The current URI for this page, for reference purposes) |
- Depositors only (login required):
