Goberdhan, D.C.I. and Wilson, C. (1998) JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective. Bioessays, 20 (12). pp. 1009-1019. ISSN 0265-9247.
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c-Jun N-terminal kinases (JNKs) are intracellular stress-activated signalling molecules, which are controlled by a highly evolutionarily conserved signalling cascade. In mammalian cells, JNKs are regulated by a wide variety of cellular stresses and growth factors and have been implicated in the regulation of remarkably diverse biological processes, such as cell shape changes, immune responses and apoptosis. How can such different stimuli activate the JNK path way and what roles does JNK play in vivo? Molecular genetic analysis of the Drosophila JNK gene has started to provide answers to these questions, confirming the role of this molecule in development and stress responses and suggesting a conserved function for JNK signalling in processes such as wound healing. Here, we review this work and discuss how future experiments in Drosophila should reveal the cell type-specific mechanisms by which JNKs perform their diverse functions.
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||R.F. Xu|
|Date Deposited:||17 Apr 2009 15:50|
|Last Modified:||17 Apr 2009 15:50|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17772 (The current URI for this page, for reference purposes)|
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