Temperature induced aggregation in aqueous solution of a series of PEO-PPO-PEO copolymers

Gaisford, Simon and Beezer, Anthony E. and Mitchell, John C. and Bell, Paul C. and Fakorede, Faluke and Finnie, Jill K. and Williams, Stuart J. (1998) Temperature induced aggregation in aqueous solution of a series of PEO-PPO-PEO copolymers. International Journal of Pharmaceutics, 174 (1-2). pp. 39-46. ISSN 0378-5173. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/S0378-5173(98)00223-3

Abstract

The temperature induced aggregation phenomena of a series of poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1-15 mg ml(-1)). Initial experiments were performed using two different dyes (1,6-diphenyl-1,3,5-hexatriene (DPH) and I-2) so that the performance of each indicator for studying poloxamer aggregation could be determined. Subsequently, the onset temperatures (T-o) and temperature maxima (T-m) for the aggregation processes of 19 poloxamers were determined, using I-2 as an indicator. The aggregation temperature was observed to be dependent on both molecular mass and solution concentration for polymers comprising the same percent PEG, the aggregation temperature decreasing with increasing mass and/or increasing concentration.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: R.F. Xu
Date Deposited: 30 Jun 2009 10:37
Last Modified: 09 May 2014 08:04
Resource URI: http://kar.kent.ac.uk/id/eprint/17753 (The current URI for this page, for reference purposes)
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