Gaisford, S. and Beezer, A.E. and Mitchell, J.C. and Bell, P.C. and Fakorede, F. and Finnie, J.K. and Williams, S.J. (1998) Temperature induced aggregation in aqueous solution of a series of PEO-PPO-PEO copolymers. International Journal of Pharmaceutics, 174 (1-2). pp. 39-46. ISSN 0378-5173.
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The temperature induced aggregation phenomena of a series of poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1-15 mg ml(-1)). Initial experiments were performed using two different dyes (1,6-diphenyl-1,3,5-hexatriene (DPH) and I-2) so that the performance of each indicator for studying poloxamer aggregation could be determined. Subsequently, the onset temperatures (T-o) and temperature maxima (T-m) for the aggregation processes of 19 poloxamers were determined, using I-2 as an indicator. The aggregation temperature was observed to be dependent on both molecular mass and solution concentration for polymers comprising the same percent PEG, the aggregation temperature decreasing with increasing mass and/or increasing concentration.
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Physical Sciences|
|Depositing User:||R.F. Xu|
|Date Deposited:||30 Jun 2009 10:37|
|Last Modified:||30 Jun 2009 10:37|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17753 (The current URI for this page, for reference purposes)|
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