Beezer, A.E. and Willson, R.J. and Mitchell, J.C. and Hills, A.K. and Gaisford, S. and Wood, E. and Connor, J.A. (1998) Thermodynamic and kinetic parameters from isothermal heat conduction microcalorimetry. In: Pure and Applied Chemistry. Medicinal Chemistry Symposium, 70. Blackwell Science Ltd, Oxon, England pp. 633-638.
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Recent developments have led to a general procedure that allows the analysis of microcalorimetric data to determine both kinetic and thermodynamic parameters. This makes microcalorimetry a technique with a potential for the accurate prediction of long-term stability, and excipient compatibility, of pharmaceutical compounds. The data presented here show the uses and limitations of this general method when applied to simple solution phase reactions, that are fast to medium term in duration, and suggest how the method may be extended to more complex heterogeneous systems that reflect cases which may be encountered industrially.
|Item Type:||Conference or workshop item (Paper)|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||I. Ghose|
|Date Deposited:||05 Oct 2009 07:12|
|Last Modified:||05 Oct 2009 07:12|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17581 (The current URI for this page, for reference purposes)|
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