Donor-derived Plasmodium vivax infection following volunteer unrelated bone marrow transplantation

O'Donnell, J. and Goldman, J.M. and Wagner, K. and Ehinger, G. and Martin, Neil D. T. and Leahy, M. and Kariuki, N. and Roberts, I. (1998) Donor-derived Plasmodium vivax infection following volunteer unrelated bone marrow transplantation. Bone Marrow Transplantation, 21 (3). pp. 313-314. ISSN 0268-3369. (The full text of this publication is not available from this repository)

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Abstract

A 14-year-old girl from the UK underwent volunteer unrelated donor bone marrow transplant (VUD BMT) for accelerated phase chronic myeloid leukaemia, On day +40 she became febrile, and peripheral blood smears demonstrated a 1% Plasmodium vivax parasitaemia, Although she had never been outside the UK, her male donor had documented Plasmodium vivax infection during a vacation in Papua New Guinea, Following appropriate treatment, he had been asymptomatic for 11 months before marrow harvesting. This is the first case report of malarial transmission by VUD BMT, and illustrates the potential problem of recrudescence of latent, dormant forms of Plasmodium vivax infection following transplantation into an immune-compromised recipient, Even after appropriate therapy, malarial infection should be included in the differential diagnosis for all post-transplant febrile episodes.

Item Type: Article
Subjects: R Medicine
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.A. Ziai
Date Deposited: 29 Jun 2011 08:16
Last Modified: 14 Jul 2014 12:36
Resource URI: http://kar.kent.ac.uk/id/eprint/17478 (The current URI for this page, for reference purposes)
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