Determination of log P-app for drug transfer to microbial cellular systems via the Taylor-Aris modified diffusion technique

Montanari, Maria Luiza C. and Montanari, Carlos A. and Veloso, Dorila Pilow and Beezer, Anthony E. and Mitchell, John C. and Volpe, Pedro L. O. (1998) Determination of log P-app for drug transfer to microbial cellular systems via the Taylor-Aris modified diffusion technique. In: 11th European Symposium on Quantitative Structure-Activity Relationships - Computer-Assisted Lead Finding and Optimization, September 1-6, 1996, Lausanne, Switzerland. (The full text of this publication is not available from this repository)

The full text of this publication is not available from this repository. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1002/(SICI)1521-3838(199804)1...

Abstract

Partitioning is a key process in QSAR studies. Experimental and calculated log P can be obtained. In the search for new methods of obtaining partition coefficients we have modified the Taylor-Aris diffusion technique to allow the direct measurement of log P within the cell system itself. This technique is applied successfully to two different cell systems and an extrathermodynamic equation between log P for Escherichia coli and Saccharomyces cerevisiae seems to be a promising way of obtaining this parameter directly from them.

Item Type: Conference or workshop item (Paper)
Additional information: Issue: 2 Document Type: Proceedings Paper
Uncontrolled keywords: Taylor-Aris diffusion technique; log PTA; Escherichia coli; Saccharomyces cerevisiae; QSRR
Subjects: R Medicine > R Medicine (General)
Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: M.A. Ziai
Date Deposited: 29 Jun 2011 08:14
Last Modified: 09 May 2014 08:13
Resource URI: http://kar.kent.ac.uk/id/eprint/17453 (The current URI for this page, for reference purposes)
  • Depositors only (login required):