Montanari, M.L.C. and Montanari, C.A. and Veloso, D.P. and Beezer, A.E. and Mitchell, J.C. and Volpe, P.L.O. (1998) Determination of log P-app for drug transfer to microbial cellular systems via the Taylor-Aris modified diffusion technique. In: 11th European Symposium on Quantitative Structure-Activity Relationships - Computer-Assisted Lead Finding and Optimization, September 1-6, 1996, Lausanne, Switzerland.
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Partitioning is a key process in QSAR studies. Experimental and calculated log P can be obtained. In the search for new methods of obtaining partition coefficients we have modified the Taylor-Aris diffusion technique to allow the direct measurement of log P within the cell system itself. This technique is applied successfully to two different cell systems and an extrathermodynamic equation between log P for Escherichia coli and Saccharomyces cerevisiae seems to be a promising way of obtaining this parameter directly from them.
|Item Type:||Conference or workshop item (Paper)|
|Additional information:||Issue: 2 Document Type: Proceedings Paper|
|Uncontrolled keywords:||Taylor-Aris diffusion technique; log PTA; Escherichia coli; Saccharomyces cerevisiae; QSRR|
|Subjects:||R Medicine > R Medicine (General)
Q Science > QD Chemistry
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||M.A. Ziai|
|Date Deposited:||29 Jun 2011 08:14|
|Last Modified:||29 Jun 2011 08:14|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17453 (The current URI for this page, for reference purposes)|
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