Sommerdijk, Najm and Wright, J.D. (1998) Matrix effects on selective chemical sensing by sol-gel entrapped complexing agents. Journal of Sol-Gel Science and Technology, 13 (1-3). pp. 565-568. ISSN 0928-0707.
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Changes in the selectivity of molecular recognition systems on sol-gel entrapment are reported. Thermodynamic effects are exemplified by studies of the metal-ion complexing agent Eriochrome Cyanine R (ECR). In aqueous solution this binds strongly and selectively to Al3+, whereas in a TMOS-based sol-gel matrix it is selective for CU2+. Thermodynamic effects, due to restricted translational freedom of water molecules or different solvent structure and isolation of ligands, can explain these observations. Effects of entrapment on molecular recognition by a large conformationally flexible molecule have been studied using a tr-is-terminated PAMAM dendrimer. The dendrimer conformation and its complexation with CU2+ changes on entrapment, and binding of aromatic carboxylic acids such as ibuprofen can be detected by changes in visible absorption and surface plasmon resonance using spun films of the sol-gel composite. These effects show that in addition to providing a porous entrapment matrix of good optical quality, sol-gels may be used to alter the binding characteristics of the entrapped receptors.
|Uncontrolled keywords:||composites; chemical sensing; spectrophotometry; surface plasmon resonance|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group
Faculties > Science Technology and Medical Studies > School of Physical Sciences
|Depositing User:||Tara Puri|
|Date Deposited:||01 Jul 2009 17:13|
|Last Modified:||01 Jul 2009 17:13|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17162 (The current URI for this page, for reference purposes)|
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