Bushell, M.E. and Bull, A.T. (1999) Sporulation at minimum specific growth rate in Aspergillus nidulans chemostat culture predicted using protein synthesis efficiency estimations. Journal of Basic Microbiology, 39 (5-6). pp. 293-298. ISSN 0233-111X.
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Ribosomal efficiency (RE) estimates provide a quantitative descriptor of intrinsic growth rate of cell populations using readily-obtainable experimental data. In Aspergillus nidulans chemostat cultures, RE increased linearly with growth rate over the range 25-60% of maximum growth rate (mu(max)) consistent with increasing ribosomal usage with increased growth rate. Above 60%, RE did not in crease significantly, suggesting that all ribosomes were functional at 60% of mu(max), further increases in growth rate, presumably resulting from increased polypeptide chain elongation rate. Extrapolating the linear part of the RE/growth rate curve predicted zero RE at a growth rate of 0.04 h(-1). Chemostat steady state cultures at 0.04 h(-1) contained spores (conidia), apparently undergoing a continuous sporulation/germination cycle. We propose that the RE estimates provide a means of predicting the value of minimum specific growth rate (mu(min)) below which net growth cannot take place.
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||M. Nasiriavanaki|
|Date Deposited:||03 Jul 2009 06:57|
|Last Modified:||03 Jul 2009 06:57|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/17156 (The current URI for this page, for reference purposes)|
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