Translation termination and its regulation in eukaryotes: Recent insights provided by studies in yeast

Mugnier, Pierre M. and Tuite, Mick F. (1999) Translation termination and its regulation in eukaryotes: Recent insights provided by studies in yeast. Biochemistry-Moscow, 64 (12). pp. 1360-1366. ISSN 0006-2979. (The full text of this publication is not available from this repository)

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Abstract

In protein synthesis, the arrival of one or other of the three stop codons in the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two proteins, eRF1 and eRF3. eRF1 is responsible for the hydrolysis of the peptidyl-tRNA, while eRF3 provides a GTP-dependent function, although its precise role remains to be defined. Recent findings on translation termination and its regulation from studies in the yeast Saccharomyces cerevisiae are reviewed and the potential role of eRF3 is discussed.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: I.T. Ekpo
Date Deposited: 30 Mar 2009 19:59
Last Modified: 10 Jun 2014 12:44
Resource URI: http://kar.kent.ac.uk/id/eprint/16951 (The current URI for this page, for reference purposes)
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