Montanari, M.L.C. and Beezer, A.E. and Montanaric, C.A. (1999) QSAR based on biological microcalorimetry - The interaction of Saccharomyces cerevisiae with hydrazides. In: International Symposium on Calorimetry and Chemical Thermodynamics. Elsevier Science Bv, Netherlands pp. 91-97.
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Calorimetry has been used as a rapid method for the determination of bioactivity. Some previous studies have been concerned with its applicability to derive structure activity relationships (SARs), which can in turn guide the synthetic chemisty through the synthesis of new chemical entities with improved antimicrobial potencies. However, earlier studies do not point out the use and importance of calorimetry in deriving quantitative structure activity relationships (QSARs), a field where it is possible not only to Set information on SARs, but insight into modes of action can also be envisaged. In this paper we describe a QSAR based on biological microcalorimetry for a set of antimicrobial hydrazides acting against Saccharomyces cerivisiae. Results show that an extrathermodynamic relationship can be drawn based upon microcalorimetrically measured biopotencies and partitioning (log P-TA) using the same cell system.
|Item Type:||Conference or workshop item (Paper)|
|Uncontrolled keywords:||QSAR; biological microcalorimetry; Saccharomyces cerevisiae|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Physical Sciences|
|Depositing User:||I.T. Ekpo|
|Date Deposited:||14 Sep 2009 07:48|
|Last Modified:||14 Sep 2009 07:48|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/16937 (The current URI for this page, for reference purposes)|
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