QSAR based on biological microcalorimetry - The interaction of Saccharomyces cerivisiae with hydrazides (vol 328, pg 91, 1999)

Montanari, M.L.C. and Beezer, A.E. and Montanaric, C.A. (1999) QSAR based on biological microcalorimetry - The interaction of Saccharomyces cerivisiae with hydrazides (vol 328, pg 91, 1999). Thermochimica Acta, 333 (2). pp. 91-97. ISSN 0040-6031. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/S0040-6031(98)00628-5

Abstract

Calorimetry has been used as a rapid method for the determination of bioactivity. Some previous studies have been concerned with its applicability to derive structure activity relationships (SARs), which can in turn guide the synthetic chemisty through the synthesis of new chemical entities with improved antimicrobial potencies. However, earlier studies do not point out the use and importance of calorimetry in deriving quantitative structure activity relationships (QSARs), a field where it is possible not only to get information on SARs, but insight into modes of action can also be envisaged. In this paper we describe a QSAR based on biological microcalorimetry for a set of antimicrobial hydrazides acting against Saccharomyces cerivisiae. Results show that an extrathermodynamic relationship can be drawn based upon microcalorimetrically measured biopotencies and partitioning (log PTA) using the same cell system.

Item Type: Article
Additional information:
Uncontrolled keywords: QSAR; Biological microcalorimetry; Saccharomyces cerivisiae
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: I.T. Ekpo
Date Deposited: 18 Sep 2009 07:30
Last Modified: 18 Sep 2009 07:30
Resource URI: http://kar.kent.ac.uk/id/eprint/16936 (The current URI for this page, for reference purposes)
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