Meek, J.H. and Elwell, C.E. and McCormick, D.C. and Edwards, A.D. and Townsend, J.P. and Stewart, A.L. and Wyatt, J.S. (1999) Abnormal cerebral haemodynamics in perinatally asphyxiated neonates related to outcome. Archives of Disease in Childhood, 81 (2). F110-F115. ISSN 0003-9888.
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Aim-To measure changes in cerebral haemodynamics during the first 24 hours of life following perinatal asphyxia, and relate them to outcome. Methods-Cerebral blood volume (CBV), its response (CBVR) to changes in arterial carbon dioxide tension (PaCO2), and cerebral blood flow (CBF) were measured using near infrared spectroscopy (NIRS) in 27 term newborn infants with clinical and/or biochemical evidence consistent with perinatal asphyxia. Results-Both CBF and CBV were higher on the first day of life in the infants with adverse outcomes, and a CBV outside the normal range had a sensitivity of 86% for predicting death or disability. The mean (SD) CBVR on the first day of life was 0.13 (0.12) ml/100 g/1/kPa, which, in 71% of infants, was below the lower 95% confidence Limit for normal subjects. Conclusion-An increase in CBV on the first day of life is a sensitive predictor of adverse outcome. A reduction in CBVR is almost universally seen following asphyxia, but is not significantly correlated with severity of adverse outcome.
|Additional information:||Special Issue: Sp. Iss. SI|
|Uncontrolled keywords:||perinatal asphyxia; cerebral haemodynamics|
|Subjects:||R Medicine > RJ Pediatrics|
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||I.T. Ekpo|
|Date Deposited:||21 Sep 2009 07:06|
|Last Modified:||21 Sep 2009 07:06|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/16932 (The current URI for this page, for reference purposes)|
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