Hall, D.A. and Strange, P.G (1999) Comparison of the ability of dopamine receptor agonists to inhibit forskolin-stimulated adenosine 3 ' 5 '-cyclic monophosphate (cAMP) accumulation via D-2L (long isoform) and D-3 receptors expressed in Chinese hamster ovary (CHO) cells. Biochemical Pharmacology, 58 (2). pp. 285-289. ISSN 0006-2952.
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| Official URL http://dx.doi.org/10.1016/S0006-2952(99)00101-X |
Abstract
The pharmacological properties of the human D-2L (long isoform) and rat D-3 dopamine receptors in functional assays were examined. A range of dopamine agonists were assessed for their ability to inhibit adenosine 3'5' cyclic monophosphate (cAMP) accumulation via the two receptors expressed stably in Chinese hamster ovary cells. Dopamine caused a significantly greater maximal inhibition (P < 0.05) of cAMP accumulation via the D-2L receptor (similar to 70%) as compared to the D-3 receptor (similar to 50%). The pattern of agonist effects was different at the two receptors. The absolute and relative potencies for inhibition of cAMP accumulation were different for a range of agonists acting at the two receptors. Similarly, the maximal inhibitions achieved by a range of agonists were different for the two receptors.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | dopamine; D-3 receptor; D-2L receptor; adenylyl cyclase |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | I.T. Ekpo |
| Date Deposited: | 21 Jun 2009 21:51 |
| Last Modified: | 21 Jun 2009 21:51 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/16829 (The current URI for this page, for reference purposes) |
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