Usher, M. and Cohen, J.D. and Servan-Schreiber, D. and Rajkowski, J. and Aston-Jones, G. (1999) The role of locus coeruleus in the regulation of cognitive performance. Science, 283 (5401). pp. 549-554. ISSN 0036-8075.
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Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electronic coupling in LC may play an important role in attentional modulation and the regulation of goat-directed versus exploratory behaviors.
|Subjects:||B Philosophy. Psychology. Religion > BF Psychology
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculties > Social Sciences > School of Psychology|
|Depositing User:||F.D. Zabet|
|Date Deposited:||20 Mar 2009 11:14|
|Last Modified:||20 Mar 2009 11:14|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/16699 (The current URI for this page, for reference purposes)|
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