Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations

Hong, S.E. and Shugart, Y.Y. and Huang, D.T. and Shahwan, S.A. and Grant, P.E. and Hourihane, J.O.B. and Martin, N.D.T. and Walsh, C.A. (2000) Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nature Genetics, 26 (1). pp. 93-96. ISSN 1061-4036. (The full text of this publication is not available from this repository)

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Abstract

Normal development of the cerebral cortex requires long-range migration of cortical neurons from proliferative regions deep in the brain. Lissencephaly ("smooth brain." from "lissos," meaning smooth, and "encephalos," meaning brain) is a severe developmental disorder in which neuronal migration is impaired, leading to a thickened cerebral cortex whose normally folded contour is simplified and smooth. Two identified lissencephaly genes(1-3) do not account for all known cases(4), and additional lissencephaly syndromes have been described(5). An autosomal recessive form of lissencephaly (LCH) associated with severe abnormalities of the cerebellum, hippocampus and brainstem maps to chromosome 7q22, and is associated with two independent mutations in the human gene encoding reelin (RELN). The mutations disrupt splicing of RELN cDNA, resulting in low or undetectable amounts of reelin protein. LCH parallels the reeler mouse mutant (Reln(rl)). in which Rein mutations cause cerebellar hypoplasia, abnormal cerebral cortical neuronal migration and abnormal axonal connectivity(6,7). RELN encodes a large (388 kD) secreted proteins that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor (VLDLR), the apolipoprotein E receptor 2 (ApoER2; refs 9-11), alpha 3 beta 1 integrin(12) and protocadherins(13). Although reelin was previously thought to function exclusively in brain, some humans with RELN mutations show abnormal neuromuscular connectivity and congenital lymphoedema, suggesting previously unsuspected functions for reelin in and outside of the brain.

Item Type: Article
Subjects: R Medicine
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Tizard
Depositing User: O.O. Odanye
Date Deposited: 03 Apr 2009 09:31
Last Modified: 12 Jun 2012 09:41
Resource URI: http://kar.kent.ac.uk/id/eprint/16231 (The current URI for this page, for reference purposes)
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