Hale, A.S. and Azorin, J.M and Kasper, S. and Maier, W. and Syvalahti, E. and Van der Burght, M. and Sloth-Nielsen, M. and Wehnert, A. (2000) Sertindole is associated with a low level of extrapyramidal symptoms in schizophrenic patients: Results of a phase III trial. International Journal of Psychiatry in Clinical Practice, 4 (1). pp. 47-54. ISSN 1365-1501.
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OBJECT: The objective of this double-blind, multicentre study was to evaluate four noses of sertindole and haloperidol 10 mg. METHOD: The 617 schizophrenic patients were randomized to receive sertindole 8, 16, 20 or 24 mg/day or haloperidol 10 mg/day. Patients were assessed for extrapyramidal symptoms (EPS) using the Simpson-Angus Scale (SAS) and Barnes Akathisia Scale (BAS), and for movement disorders using the Abnormal Involuntary Movement Scale (AIMS). RESULTS: Patients receiving haloperidol experienced significantly more EPS than patients receiving sertindole, supporting observations mane in. previous studies. The incidence of adverse events was similar for all noses of sertindole. SAS and BAS scores were significantly worse in the haloperidol,group than in. the sertindole groups. There were significantly greater increases in mean QT(c) interval in the sertindole groups than in the haloperidol group. Sertindole did not cause sedation. CONCLUSIONS: Sertindole is well tolerated and does not cause the debilitating EPS associated with traditional antipsychotic drugs.
|Additional information:||Alternate email: PROFASHALE@aol.com|
|Uncontrolled keywords:||antipsychotic agents; phase III clinical trial; sertindole; extrapyramidal symptoms; schizophrenia|
|Subjects:||B Philosophy. Psychology. Religion > BF Psychology|
|Divisions:||Faculties > Social Sciences > School of Psychology|
|Depositing User:||O.O. Odanye|
|Date Deposited:||01 May 2009 00:35|
|Last Modified:||13 Jun 2012 08:14|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/16179 (The current URI for this page, for reference purposes)|
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