LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1 alpha protein

Sumbayev, Vadim V (2008) LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1 alpha protein. FEBS Letters, 582 (2). pp. 319-326. ISSN 0014-5793. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/j.febslet.2007.12.024

Abstract

Toll-like receptor 4 (TLR4) is required for recognition of lipopolysaccharide (LPS) of Gram-negative bacteria and induction of the innate immune response to them. Nevertheless, the involvement of some crucial pathways in TLR4 signalling is poorly understood. Here, we report that LPS-induced TLR4 signalling triggers cross talk of HIF-1 alpha and ASK1 in THP-1 human myeloid monocytic leukaemia cells. Both pathways are activated via redox-dependent mechanism associated with tyrosine kinase/phospholipase C-1 gamma-mediated activation of protein kinase C alpha/beta, which are known to activate NADPH oxidase and the production of reactive oxygen species that activate both HIF-1 alpha and ASK1. ASK1 contributes to the stabilisation of HIF-1 alpha, most likely via activation of p38 MAP kinase.

Item Type: Article
Uncontrolled keywords: Toll-like receptor; inflammation and innate immunity; HIF-1 alpha; apoptosis; MAP kinase cascade
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Louise Dorman
Date Deposited: 26 Aug 2009 14:32
Last Modified: 24 Apr 2014 07:57
Resource URI: http://kar.kent.ac.uk/id/eprint/15244 (The current URI for this page, for reference purposes)
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