Chu, C. and Blomfield, I.C. (2006) Orientational Control is an Efficient Control Mechanism for Phase Switching in the E coli fim System. Journal of Theoretical Biology, 244 (3). pp. 541-551. ISSN 0022-5193.
The 'fim' system in 'E. coli' controls the expression of type-1 fimbriae. These are hair-like structures that can be used to attach to host cells. Fimbriation is controlled by a mechanism called ''orientational control''. We present two families of models for orientational control to understand the details of how it works. We find that the main benefits of orientational control are that (i) it allows rapid adjustment of fimbriation levels in response to a change of environmental conditions while (ii) keeping the overall frequencies with which a cell switches between the fimbriate state and the afimbriate state low. The main reason for the efficiency of orientational control in regulation of fimbriation levels is that it keeps the system far from its steady state.
|Uncontrolled keywords:||Phase variation; fim; Steady-state; E. coli|
|Subjects:||Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Computing > Applied and Interdisciplinary Informatics Group|
|Depositing User:||Mark Wheadon|
|Date Deposited:||24 Nov 2008 18:04|
|Last Modified:||09 May 2012 09:05|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/14516 (The current URI for this page, for reference purposes)|
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