Sumbayev, V. and Yasinksa, I.M. (2007) Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species. Scandinavian Journal of Immunology, 65 (5). pp. 399-406. ISSN 0300-9475.
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Recent reports devoted to the field of oxygen sensing outline that signalling molecules such as nitric oxide/nitric oxide derived species as well as cytokines and other inflammatory mediators participate in hypoxic signal transduction. In the present review, we summarize the current knowledge about the role of nitric oxide and reactive nitrogen species (RNS) derived from it in hypoxic signal transduction and particularly in accumulation/de-accumulation of hypoxia inducible factor I alpha (HIF-1 alpha) protein, which is critical not only for cellular adaptation to low oxygen availability but also for generation of inflammatory and innate immune responses. After brief description of nitric oxide and other RNS as multifunctional messengers we analyse and discuss the RNS-dependent accumulation of HIF-1 alpha protein under normoxia followed by discussion of the mechanisms of nitric oxide (NO)-dependent enzyme-regulared degradation of HIF-1 alpha protein under low oxygen availability.
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculties > University wide - Teaching/Research Groups|
|Depositing User:||Stephen Holland|
|Date Deposited:||19 Dec 2007 18:55|
|Last Modified:||14 Jan 2010 14:03|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/1418 (The current URI for this page, for reference purposes)|
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