Biagini, S.C.G. and Gibson, S.E. and Keen, S.P. (1998) Cross-metathesis of unsaturated alpha-amino acid derivatives. Journal of the Chemical Society-Perkin Transactions 1 (16). pp. 2485-2499. ISSN 0300-922X.
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| Official URL http://dx.doi.org/10.1039/a804147d |
Abstract
Cross-metathesis of homoallylglycine derivatives with aryl- and alkyl-substituted alkenes using the ruthenium catalyst (Cy3P)(2)Cl2Ru=CHPh 1 has been achieved in 43-55 and 55-66% yield respectively. Allylglycine, vinylglycine and dehydroalanine derivatives have also been examined. Whilst cross-metathesis of allylglycine derivatives with alkyl-substituted alkenes using catalyst 1 may be regarded as a synthetically useful procedure, cross-metathesis reactions of vinylglycine and dehydroalanine derivatives using catalyst 1 are non-viable. Attachment of FmocHagOH 13 to a capped Wang resin, cross-metathesis with dodec-1-ene, and product removal from the resin gives the cross-metathesis product in 74% yield based on FmocHagOH.
| Item Type: | Article |
|---|---|
| Additional information: | Times Cited: 36 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group Faculties > Science Technology and Medical Studies > School of Physical Sciences |
| Depositing User: | Stefano C G Biagini |
| Date Deposited: | 26 Jun 2009 08:52 |
| Last Modified: | 26 Jun 2009 08:52 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/13239 (The current URI for this page, for reference purposes) |
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