Batters, C. and Arthur, C.P. and Lin, A. and Porter, J. and Geeves, M.A. and Milligan, R.A. and Molloy, J.E. and Coluccio, L.M. (2004) Myo1c is designed for the adaptation response in the inner ear. Embo J, 23 (7). pp. 1433-40. ISSN 0261-4189 .
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| Official URL http://dx.doi.org/ 10.1038/sj.emboj.7600169 |
Abstract
The molecular motor, Myo1c, a member of the myosin family, is widely expressed in vertebrate tissues. Its presence at strategic places in the stereocilia of the hair cells in the inner ear and studies using transgenic mice expressing a mutant Myo1c that can be selectively inhibited implicate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for balance. Here, we have studied the structural, mechanical and biochemical properties of Myo1c to gain an insight into how this molecular motor works. Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.
| Item Type: | Article |
|---|---|
| Additional information: | 0261-4189 (Print) Journal Article |
| Uncontrolled keywords: | *Adaptation, Biological Adenosine Diphosphate/metabolism Animals Cochlea/*physiology Cryoelectron Microscopy Hair Cells/cytology/*metabolism Mechanotransduction, Cellular/*physiology Mice Models, Molecular Myosins/chemistry/*metabolism/ultrastructure Rats Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Stress, Mechanical |
| Subjects: | Q Science |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | Michael Geeves |
| Date Deposited: | 29 May 2009 06:00 |
| Last Modified: | 29 May 2009 06:00 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/13200 (The current URI for this page, for reference purposes) |
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