Tempest, Helen G. and Griffin, D.K. (2005) The cytogenetics of preimplantation human development: insights provided by traditional and novel techniques. Chromosoma, 114 (4). pp. 295-299. ISSN 0009-5915 .
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| Official URL http://dx.doi.org/10.1007/s00412-005-0340-x |
Abstract
Our understanding of the incidence and origin of chromosome abnormalities in human preimplantation embryos is very limited due to the necessary ethical constraints involved in studying such material and the limited data ultimately produced. Several studies have addressed this issue, however, using techniques such as interphase fluorescence in situ hybridisation, modified G-banding preparation and the use of single-cell comparative genomic hybridisation (CGH). This review discusses the use of these techniques in assessing chromosome abnormalities in this, the earliest of human developmental stages. In addition, the prospects for the clinical use of CGH are discussed.
| Item Type: | Article |
|---|---|
| Additional information: | 10.1007/s00412-005-0340-x 0009-5915 |
| Uncontrolled keywords: | Aneuploidy Blastocyst Cytogenetics Humans In Situ Hybridization, Fluorescence Interphase Nucleic Acid Hybridization |
| Subjects: | Q Science |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | Darren Griffin |
| Date Deposited: | 12 Sep 2008 22:51 |
| Last Modified: | 13 Mar 2012 09:57 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/12494 (The current URI for this page, for reference purposes) |
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