Conservation of chromosome arrangement and position of the X in mammalian sperm suggests functional significance

Greaves, I.K. and Rens, W. and Ferguson-Smith, M.A. and Griffin, D.K. and Marshall Graves, J.A. (2003) Conservation of chromosome arrangement and position of the X in mammalian sperm suggests functional significance. Chromosome Research: An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology, 11 (5). pp. 503-512. ISSN 0967-3849. (The full text of this publication is not available from this repository)

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Abstract

We used chromosome painting to show directly that chromosomes occupy fixed positions in the nuclei of mammal but not chicken sperm. We found that the positions of homologous chromosomes are conserved in sperm of two marsupial species that diverged 50-60 million years ago. We also discovered that the X chromosome lies in the region that makes first contact with the egg in marsupial and monotreme mammals, as well as eutherians, and suggest that this position may be related to its propensity for inactivation, and its high rate of loss from ICSI embryos. We propose that nuclear architecture in sperm is important for spatial chromatin differentiation and normal development of the fertilized egg, and evolved along with mammal-specific regulatory systems such as X inactivation and genomic imprinting.

Item Type: Article
Additional information: 12971725 0967-3849
Uncontrolled keywords: Animals Cell Nucleus Chickens Chromosome Painting Chromosome Positioning Evolution Male Marsupialia Platypus Spermatozoa X Chromosome
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 10 Sep 2008 10:00
Last Modified: 29 May 2012 09:48
Resource URI: http://kar.kent.ac.uk/id/eprint/12476 (The current URI for this page, for reference purposes)
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