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Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly

Wolf, H., Grunwald, M., Kruggel, F., Riedel-Heller, S., Angerhofer, S., Hojjatoleslami, Ali, Hensel, A., Arendt, T., Gertz, H.J. (2001) Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of Aging, 22 (2). pp. 177-186. ISSN 0197-4580. (doi:10.1016/S0197-4580(00)00238-4) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12308)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/S0197-4580(00)00238-4

Abstract

The sensitivity of MRI volumetric measures to detect cognitive dysfunction is examined in 39 participants of an epidemiological field study (age 75-85, MMSE 19-30). According to Clinical dementia rating (CDR), 17 subjects had normal cognition (CDR 0), 12 had questionable (CDR 0.5) and 10 mild dementia (CDR 1). Discriminant analysis based on four hippocampal measures resulted in a correct classification of 76.9% of all subjects. Left-sided and posterior hippocampal measures were more responsible for group discrimination than right-sided and anterior measures. In CDR 0.5, a significant hippocampal volume reduction of 14.3% vs.11.3% (left vs, right) relative to normal was found. The right hippocampus was significantly greater than the left in CDR 0 and CDR 0.5, but not in CDR 1. The magnitude of non-directional hippocampal asymmetry increased with decreasing cognitive state. We conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for Alzheimer's disease in the elderly population. (C) 2001 Elsevier Science Inc. All rights reserved.

Item Type: Article
DOI/Identification number: 10.1016/S0197-4580(00)00238-4
Uncontrolled keywords: hippocampus MRI volumetry aging cognition mild cognitive impairment mild dementia Alzheimer's disease asymmetry laterality clinical dementia rating population-based
Subjects: R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
T Technology > TA Engineering (General). Civil engineering (General) > TA1637 Image processing
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research
Depositing User: M.P. Stone
Date Deposited: 11 Oct 2008 23:00 UTC
Last Modified: 16 Nov 2021 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/12308 (The current URI for this page, for reference purposes)

University of Kent Author Information

Hojjatoleslami, Ali.

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