Wolf, H. and Grunwald, M. and Kruggel, F. and Riedel-Heller, S. and Angerh”fer, S. and Hojjatoleslami, A. and Hensel, A. and Arendt, T. and Gertz, H.J. (2001) Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of Aging, 22 (2). pp. 177-186. ISSN 0197-4580.
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The sensitivity of MRI volumetric measures to detect cognitive dysfunction is examined in 39 participants of an epidemiological field study (age 75-85, MMSE 19-30). According to Clinical dementia rating (CDR), 17 subjects had normal cognition (CDR 0), 12 had questionable (CDR 0.5) and 10 mild dementia (CDR 1). Discriminant analysis based on four hippocampal measures resulted in a correct classification of 76.9% of all subjects. Left-sided and posterior hippocampal measures were more responsible for group discrimination than right-sided and anterior measures. In CDR 0.5, a significant hippocampal volume reduction of 14.3% vs.11.3% (left vs, right) relative to normal was found. The right hippocampus was significantly greater than the left in CDR 0 and CDR 0.5, but not in CDR 1. The magnitude of non-directional hippocampal asymmetry increased with decreasing cognitive state. We conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for Alzheimer's disease in the elderly population. (C) 2001 Elsevier Science Inc. All rights reserved.
|Uncontrolled keywords:||hippocampus MRI volumetry aging cognition mild cognitive impairment mild dementia Alzheimer's disease asymmetry laterality clinical dementia rating population-based|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
T Technology > TA Engineering (General). Civil engineering (General) > TA1637 Image Analysis, Image Processing
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||M.P. Stone|
|Date Deposited:||11 Oct 2008 23:00|
|Last Modified:||11 Oct 2008 23:00|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/12308 (The current URI for this page, for reference purposes)|
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