Sinha, P.S. and Thrush, S. and Bendall, S. and Bates, T. (2002) Does radical surgery to the axilla give a Survival advantage in more severe breast cancer? European Journal of Cancer, 38 (11). pp. 1474-1477. ISSN 0959-8049.
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There is sonic evidence that more radical treatment of the axilla may improve survival in node-positive disease, but there are concerns about the resultant morbidity from axillar surgery and radiotherapy. The aim of this study was to compare the outcome of axillary node clearance with axillary sampling in similar patients by comparing loco-regional recurrence and overall survival Patients with invasive breast cancer undergoing axillary surgery between 1986 and 1997 were included. The axillary procedure performed in these patients vas either an axillary sample or a level III axillary clearance. To compare like with, the patients were separated into good. moderate and poor prognostic groups by the Nottingham Prognostic Index (NPI) and overall survival was compared by a Kaplan-Meier life table analysis and the lot, rank test. 734 consecutive patients with operable invasive breast cancer were treated by axillary clearance n=350 or sampling n=384. The mean follow-up in the clearance group vas 65 months versus 66 months in the sampled group. Local recurrence in the clearance group was 11% versus 6% in the sampled group, regional recurrence 2% versus 3% and distant metastasis 28% versus 13%. Kaplan-Meier analysis of the three prognostic groups Cor the clearance versus sampled groups showed no differences in the absolute survival (log rank: P 0.3 P 0.8 and P 0.6 for the good. moderate and poor prognostic groups. respectively). A conservative surgical approach to the axilla did not significantly increase the incidence of local or regional recurrence and the expected survival benefit from a radical axillary clearance was not apparent.
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RD Surgery
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||M.P. Stone|
|Date Deposited:||27 Mar 2009 17:59|
|Last Modified:||27 Mar 2009 17:59|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/12277 (The current URI for this page, for reference purposes)|
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