Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease

Schulze-Neick, Ingram, Hartenstein, Paulina, Li, Jia, Stiller, Brigitte, Nagdyman, Nicola, Hubler, Michael, Butrous, Ghazwan S., Petros, Andy, Lange, Peter, Redington, Andrew N. and others. (2003) Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation, 108 (10). pp. 167-173. ISSN 0009-7322. (doi:10.1161/01.cir.0000087384.76615.60) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:12271)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: https://doi.org/10.1161/01.cir.0000087384.76615.60

Abstract

Background-Increased pulmonary vascular resistance (PVR) because of congenital heart disease (CHD) may be caused by a dysfunction in endogenous pulmonary endothelial nitric oxide (NO) production. In other forms of pulmonary vascular disease with increased PVR, an elevated activity of a phosphodiesterase type 5 (PDE-5), responsible for the degradation of cyclic guanidine monophosphate (cGMP), the second messenger of endothelially produced NO, has been demonstrated. This study compares the effects of inhaled NO before and after the specific inhibition of the PDE-5 by intravenous sildenafil (Viagra T) in pre- and postoperative children with increased PVR because of CHD.

Item Type:	Article
DOI/Identification number:	10.1161/01.cir.0000087384.76615.60
Additional information:	NOT IN FILE
Subjects:	R Medicine > R Medicine (General)
Divisions:	Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research
Depositing User:	M.P. Stone
Date Deposited:	12 Sep 2008 11:24 UTC
Last Modified:	16 Nov 2021 09:50 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/12271 (The current URI for this page, for reference purposes)

University of Kent Author Information

Butrous, Ghazwan S..

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