A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

Maidment, Ian D. and Fox, Christopher and Boustani, Malaz (2005) A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia. Acta Psychiatrica Scandinavica, 111 (6). pp. 403-409. ISSN 0001-690X. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1111/j.1600-0447.2005.00516.x

Abstract

Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 - December 2004), PsychINFO (1972 December 2004), EMBASE (1980 - December 2004), CINHAL (1982 - December 2004), and the Cochrane Collaboration were searched in December 2004. Results: Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms. Conclusion: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms - in particular tremor - may limit the utility of cholinesterase inhibitors.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.P. Stone
Date Deposited: 10 Sep 2008 22:08
Last Modified: 28 May 2014 15:47
Resource URI: http://kar.kent.ac.uk/id/eprint/12199 (The current URI for this page, for reference purposes)
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