Maidment, I.D. and Fox, C. and Boustani, M. (2005) A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia. Acta Psychiatr Scand, 111 (6). pp. 403-409. ISSN 0001-690X .
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Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 - December 2004), PsychINFO (1972 December 2004), EMBASE (1980 - December 2004), CINHAL (1982 - December 2004), and the Cochrane Collaboration were searched in December 2004. Results: Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms. Conclusion: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms - in particular tremor - may limit the utility of cholinesterase inhibitors.
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||M.P. Stone|
|Date Deposited:||10 Sep 2008 22:08|
|Last Modified:||10 Sep 2008 22:08|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/12199 (The current URI for this page, for reference purposes)|
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