Retrograde amnesia and the volume of critical brain structures

Kopelman, Michael D. and Lasserson, Dan and Kingsley, Derek and Bello, Fernando and Rush, C. and Stanhope, Nicola and Stevens, Tom and Goodman, G. and Heilpern, G. and Kendall, B.E. and Colchester, Alan C. F. (2003) Retrograde amnesia and the volume of critical brain structures. Hippocampus, 13 (8). pp. 879-891. ISSN 1050-9631. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1002/hipo.10140

Abstract

There are many controversies concerning the structural basis of retrograde amnesia (RA). One view is that memories are held briefly within a medial temporal store ("hippocampal complex") before being "consolidated" or reorganised within temporal neocortex and/or networks more widely distributed within the cerebral cortex. An alternative view is that the medial temporal lobes are always involved in the storage and retrieval (reactivation) of autobiographical memories (multiple trace theory). The present study used quantitative magnetic resonance imaging (MRI) in 40 patients with focal pathology/volume loss in different sites, to examine the correlates of impairment on three different measures of RA. The findings supported the view that widespread neural networks are involved in the storage and retrieval of autobiographical and other remote memories. Brain volume measures in critical structures could account for 60% of variance on autobiographical memory measures (for incidents and facts) in diencephalic patients and for 60-68% of variance in patients with frontal lesions. Significant correlations with medial temporal lobe volume were found only in the diencephalic group, in whom they were thought to reflect thalamic changes, but not in patients with herpes encephalitis or hypoxia in whom the temporal lobes were particularly implicated. The latter finding fails to support one of the main predictions of multiple trace theory, as presently expounded. (C) 2003 Wiley-Liss, Inc.

Item Type: Article
Uncontrolled keywords: retrograde amnesia hippocampal complex MRI
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.P. Stone
Date Deposited: 10 Sep 2008 11:50
Last Modified: 14 May 2014 13:44
Resource URI: http://kar.kent.ac.uk/id/eprint/12168 (The current URI for this page, for reference purposes)
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