Livingston, G. and Katona, C. (2002) How well do antidepressants work in older people? A system review of number needed to treat. Journal of Affective Disorders, 69 (1-3). pp. 47-52. ISSN 0165-0327 .
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Objectives: To make direct comparisons between studies of antidepressant treatment of older people using Number Needed to Treat (NNT) analysis. Methods: Medline and Embase Search 1966-1999 and contact with manufacturers of antidepressant drugs asking for any relevant data on file; NNT analyses of outcome in terms of efficacy and adverse effects. Results: Most antidepressant trials show efficacy; this is less clear for moclobemide and fluoxetine. Head-to-head comparisons between antidepressants showed significant superiority for paroxetine over fluoxetine and a trend in favour of SSRIs and venlafaxine over tricyclics. Conclusions: NNT analysis is one way of providing intelligible information on antidepressant efficacy and adverse effects which can inform clinical decisions. Limitations: Many studies do not present data in a form amenable to NNT analysis. Most head-to-head comparisons between antidepressants are underpowered. (C) 2002 Elsevier Science B.V. All rights reserved.
|Uncontrolled keywords:||Mood disorder ; Human ; Review ; Toxicity ; Treatment efficiency ; Need ; Comparative study ; Psychotropic ; Antidepressant agent ; Typology ; Randomized design ; Controlled therapeutic trial ; Chemotherapy ; Treatment ; Elderly ; Depression ;|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||M.P. Stone|
|Date Deposited:||03 Oct 2008 17:18|
|Last Modified:||03 Oct 2008 17:18|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/12147 (The current URI for this page, for reference purposes)|
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