A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia

Boriani, Giuseppe and Biffi, Mauro and Bacchi, Letizia and Martignani, Cristian and Zannoli, Romano and Butrous, Ghazwan S. and Branzi, Angelo (2002) A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia. European Journal of Clinical Pharmacology, 58 (3). pp. 165-169. ISSN 0031-6970 . (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1007/s00228-002-0464-3

Abstract

Objective. To assess the haemodynamic effects of short-term treatment with dofetilide in comparison with sotalol in patients with ischaemic heart disease. Methods. Twelve patients with ischaemic heart disease and sustained ventricular tachycardia were treated with dofetilide [500 æg twice daily (b.i.d.)] or sotalol (160 mg b.i.d., randomised sequence separated by wash-out period) for 3-5 days. Right-heart catheterisation was performed at baseline and at the end of each short-term treatment phase. Results. The main findings were a significant reduction in heart rate, mean systemic pressure and cardiac index (-13%) during treatment with sotalol. Conversely, cardiac index increased significantly during dofetilide (mean percentage change 11%) with no effect on heart rate and systemic blood pressure. Conclusions. Oral dofetilide exerts favourable haemodynamic effects in comparison with D,L -sotalol following short-term oral treatment. In view of these observations, the use of dofetilide may be proposed also in patients with ventricular tachyarrhythmias associated with impaired left-ventricular function. Whether the haemodynamic differences between dofetilide and D,L -sotalol are the basis for differences in tolerability remains to be evaluated.

Item Type: Article
Subjects: R Medicine
Divisions: Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)
Depositing User: M.P. Stone
Date Deposited: 14 Sep 2008 15:43
Last Modified: 25 Apr 2014 10:29
Resource URI: http://kar.kent.ac.uk/id/eprint/12038 (The current URI for this page, for reference purposes)
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