Tuite, M.F. and Koloteva-Levine, N. (2004) Propagating prions in fungi and mammals. Molecular Cell, 14 (5). pp. 541-552. ISSN 1097-2765.
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Abstract
Prions constitute a rare class of protein, which can switch to a robust amyloid form and then propagate that form in the absence of a nucleic acid determinant, thereby creating a unique, protein-only infectious agent. Details of the mechanism that drives conversion to the prion form and then subsequent propagation of that form are beginning to emerge using a range of in vivo and in vitro approaches. Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids.
| Item Type: | Article |
|---|---|
| Additional information: | 1097-2765 (Print) Journal Article Research Support, Non-U.S. Gov't Review |
| Uncontrolled keywords: | Amyloid/metabolism Animals Cell-Free System Fungal Proteins/*metabolism Humans Mammals/*metabolism Models, Biological Prion Diseases/*metabolism/transmission Prions/chemistry/*metabolism Protein Folding Protein Structure, Tertiary/physiology |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group |
| Depositing User: | Mick Tuite |
| Date Deposited: | 02 Oct 2008 16:37 |
| Last Modified: | 31 Jul 2012 07:58 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/11315 (The current URI for this page, for reference purposes) |
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