Compelling evidence for a stepwise mechanism of the alkaline cyclisation of uridine 3 '-phosphate esters

Lonnberg, H. and Stromberg, R. and Williams, A. (2004) Compelling evidence for a stepwise mechanism of the alkaline cyclisation of uridine 3 '-phosphate esters. Organic & Biomolecular Chemistry, 2 (15). pp. 2165-2167. ISSN 1477-0520. (The full text of this publication is not available from this repository)

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Abstract

A Bronsted graph with a convex break at pK(a) (Lg) = 12.58 provides compelling evidence for an intermediate in the alkaline cyclisation of uridine 3'-phosphate esters. The transient pentacoordinated oxyphosphorane dianion intermediate collapses to reactant and cyclic uridine 2', 3'-monophosphate faster than it can pseudo-rotate and isomerise to the 2'-isomer.

Item Type: Article
Additional information: 36 ROYAL SOC CHEMISTRY 841UP
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: Maggie Francis
Date Deposited: 25 Sep 2008 16:19
Last Modified: 14 Jan 2010 14:42
Resource URI: http://kar.kent.ac.uk/id/eprint/11014 (The current URI for this page, for reference purposes)
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