The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

Nokhodchi, A. and Nazemiyeh, H. and Ghafourian, T. and Hassan-Zadeh, D. and Valizadeh, H. and Bahary, L.A.S. (2002) The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations. IL Farmaco, 57 (11). pp. 883-888. ISSN 0014-827X. (The full text of this publication is not available from this repository)

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Abstract

The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. # 2002 E´ ditions scientifiques et me´dicales Elsevier SAS

Item Type: Article
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 21 Oct 2008 16:39
Last Modified: 14 Jan 2010 14:41
Resource URI: http://kar.kent.ac.uk/id/eprint/10760 (The current URI for this page, for reference purposes)
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