A mapping and evolutionary study of porcine sex chromosome genes.

Quilter, Claire R and Blott, Sarah C and Mileham, Alan J and Affara, Nabeel and Sargent, Carole A and Griffin, Darren K. (2002) A mapping and evolutionary study of porcine sex chromosome genes. Mammalian Genome, 13 . pp. 588-594. ISSN 0938-8990. (Access to this publication is restricted)

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http://dx.doi.org/10.1007/s00335-002-3026-1

Abstract

A combination of FISH and RH mapping was used to study the evolution of sex chromosome genes in the pig. In total, 19 genes were identified, including 3 PAR genes (STS, KAL, PRK). The gene order of the porcine X Chromosome (Chr) closely resembled the human X Chr (PRK/STS/KAL-AMELX-EIF2s3X/ZFX-USP9X-DBX-SMCX), suggesting that the porcine X has undergone very little rearrangement during evolution. For the porcine Y Chr, two linkage groups of 10 NRY genes were found, and the following order was established: Ypter-(AMELY-EIF2S3Y/ZFY-USP9Y-DBY/UTY)-(TSPY-SMCY-UBE1Y-SRY)-CEN. This gene order showed greater conservation with the murine Y than with the human Y Chr. In addition, all porcine Y Chr genes mapped to Yp, which is similar to the mouse and included EIF2s3Y and UBE1Y, which are not present in humans. Interestingly, complete conservation of X/Y homologous gene order was found between the pig X and Y Chrs, indicating that the porcine Y Chr has not undergone extensive reorganisation with respect to the X. This suggests that the order of the X/Y homologous genes of the porcine X and Y Chrs may closely resemble the ancestral gene order of the eutherian sex chromosomes.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Cell & Developmental Biology Group
Depositing User: Sue Davies
Date Deposited: 19 Dec 2007 17:57
Last Modified: 30 Apr 2014 09:59
Resource URI: http://kar.kent.ac.uk/id/eprint/102 (The current URI for this page, for reference purposes)
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